Laboratory Bioreactors / Fermentors

m2p-labs GmbH

The fully scalable BioLector® manages not only to run 48 cultivations in parallel, but also to perform real time online monitoring of the most common parameters (biomass, pH, DO and GFP). Furthermore, the system controls the temperature inside the cultivation chamber, the shaking speed as well as humidity. It operates with non-invasive, optical sensors and is due to the continuous and rigorous shaking ideally suited for aerobic and anaerobic cultures. In case that there is a high or very low oxygen level required, a CO2 enriched aeration, anaerobic conditions, or the possibility for measuring Fluorescence Resonance Energy Transfer (FRET), the system can be easily upgraded with additional modules.

The Biolector® Pro version extends the proven scalable BioLector® technology with an innovative microfluidic chip for extremely exact and slow dosing down to 50 nL. More information

m2p-labs GmbH

Pipetting volume range: 10 – 900 μL
Accuracy: ± 2%

This fully automated system combines a BioLector® with the precise and accurate liquid handling of a pipetting robot. The RoboLector® autonomously prepares media compositions from a full factorial design of experiments (DoE) and allows to add inducers and feed solutions during fermentation according to a pre-defined schedule or triggered by online process signals.

The RoboLector® L comes with a two-needle liquid-handling robot and 16 different deck positions on the worktable, whereas the more sophisticated RoboLector® XL provides 8-needles and 20 different deck positions. More information

Inoxpa

INOXPA offers automated and customized CIP/SIP units to guarantee a controlled cleaning and sterilization of all elements required (tanks, pipes, pumps) in a reliable, repetitive and verifiable manner, without having to disassemble the entire process plants. The sterilization of the process plants is carried out with steam supplied by a clean steam generator. Chemical sterilization is also possible. Models include, manually operated, fully automated and mobile CIP units. The complete SIP as well as CIP circle is monitored by a PLC unit that controls every stage of the process. More information

PIERRE GUERIN TECHNOLOGIES

Volume range: 1.0/2.0/3.0/5.0/10.0 liters
Sterilization: Autoclavable
Vessel: Stainless Steel jacketed vessel
Working aspect ratio: 2
Usage: Microbial fermentation / cell culture

The customizable Tryton¡™ series of bench top bioreactors combines robustness and reliability gained from its Micro-PLC – PC based control technology. Five standard interchangeable vessels from 1 to 10 liters enable microbial fermentation and cell cultivation at laboratory scale. The Neptune™ Control system with intuitive graphical user Interface and advanced functionalities (Profile, calculation, off-line data and strategy modules) suits perfectly the needs for Research & Development or small scale production. All bioreactors comply with GMP and GAMP 5 requirements. More information

PIERRE GUERIN TECHNOLOGIES

Volume range: 15 / 30 / 50 liters
Sterilization: SIP (steam-in-place)
Vessel: Stainless steel jacketed vessel
Working aspect ratio: 1.7
Usage: Microbial fermentation

The BioPro™ Evo™ fermenters are precision culture systems designed for optimization studies, scale-up & clinical runs in GLP/GMP environment. All reactors include instruments and sensors for control and measurement of pH, pO2, dO2, CO2, temperature, weight, turbidity gas mixing etc. These instruments fit for many culture types including yeast, bacteria, fungi in batch, fed-batch or continuous modes (with appropriate accessories). More information

PIERRE GUERIN TECHNOLOGIES

Volume range: 10 to 300 liters
Sterilization: SIP (Steam-in-place)
Vessel: Stainless steel jacketed vessel
Working aspect ratio: 2
Usage: Microbial fermentation

Besides the seven standard sizes from 10 to 300 Liters, there are also custom vessels on request available; either in the S-Type design for general applications or in the G-Type design for GLP / GMP validated applications. These scalable systems offer high oxygen and thermal transfer performances due to an agitation system that combines the patented HTPG4™ three bladed impellers and a Rushton turbine. The BioPro™ Lab & Pilot series perfectly suits the application of microbial fermentation at R&D and industrial scale. More information

PIERRE GUERIN TECHNOLOGIES

Volume range: 10 to 300 liters
Sterilization: SIP (Steam-in-place)
Vessel: Stainless steel jacketed vessel
Working Aspect Ratio: 1
Use: Animal and human cell cultivation

The BioCell™ Lab & Pilot fermenters are precision culture systems suitable for animal and human cell cultivation at lab, pilot and industrial scale. The agitation system equipped with patented HTPG4™ impellers offers mixing, optimum gas transfer and maximum viability of the cells due to low shear constraints. The user-friendly Neptune™ control solution complies with GMP requirements both GAMP 5 and 21 CFR Part 11. All BioCell™ Lab & Pilot fermenters are suitable for the cultivation of either suspended or attached cells in batch, fed-batch or perfusion mode (with appropriate accessories). More information

PIERRE GUERIN TECHNOLOGIES

Volume range: 20 – 1’000 liters
Sterilization: SUB (Single Use Bioreactors)
Vessel: Single-use Bio Container
Working aspect ratio: Customizable
Use: Cell Cultivation

The Nucléo™ single-use bioreactor provides comparable functionality to conventional SIP bioreactors, but with reduced timelines, reduced budget and increased flexibility. This complete turnkey solution is perfectly adapted to the cultivation of suspended and adherent cells at very high densities and compatible with batch, fed-batch and perfusion processes. The scalability, superior mixing capabilities as well as the innovative Neptune™ control system make this instrument suitable to laboratory environments, process development centers and flexible GMP manufacturing. More information